Project description:To understand the global view of dysregulated genes and pathwyas in CRYAAN101D lenses, RNA sequencing of 2 & 4 months old CRYAAWT and CRYAAN101D lenses was carried out.

2014-05-28 | GSE57959 | GEO

Comparison of expression data of 2 & 4- months old CRYAAN101D versus CRYAAWT lenses

Project description:To understand the global view of dysregulated genes and pathwyas in CRYAAN101D lenses, RNA sequencing of 2 & 4 months old CRYAAWT and CRYAAN101D lenses was carried out. Determination of differential gene expression between CRYAAWT and CRYAAN101D in 2 & 4 months old lenses

2014-05-28 | E-GEOD-57959 | biostudies-arrayexpress

Single cell level characterization of injury-induced immune changes in 10-week-old and 95-week-old C57BL/6 knee joints

Project description:Post-traumatic Osteoarthritis (PTOA) occurs in about half of individuals who sustained articular injuries including tibial plateau fracture, meniscus tear, or an anterior cruciate ligament (ACL) rupture. Damage-associated molecular pattern (DAMP) proteins are typically secreted from injured or dying cells of the synovial joint into the surrounding environment immediately following injury which in turn recruit leukocytes to mediate debris clean-up and repair. Prior bulk RNA-seq experiments exploring organismal age-related differences following ACL rupture found an increased expression of inflammatory-response related genes in 95-week-old mice relative to 10-week-old mice. Using single-cell RNA sequencing technology we temporally explored differences in immune cell infiltration in the synovial joint in 10-week-old and 95-week-old C57BL/6 mice.

2025-07-05 | GSE236843 | GEO

Microarray data of ICR lenses at each week of age

Project description:Analysis of gene expression changes during cataract progression.

2023-10-26 | GSE230320 | GEO

Expression data from Sprague Dawley rat lenses cultured for 4 days - addition of various inhibitors

Project description:We created a rat sugar cataract model and examined the effects of various inhibitors on lens clouding. Lenses were removed from 6-week-old SD rats and cultured in M199 medium containing 30 mM galactose.

2020-03-04 | GSE135000 | GEO

Microarray data of ICR lenses

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-26 | GSE230323 | GEO

Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice

Project description:ICR-derived glomerulonephritis (ICGN) mice is a novel inbred strain of mice with a hereditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been suggested. To identify additional associative factors and to better understand onset mechanism of nephrotic syndrome in ICGN mice, comprehensive gene expression analysis using DNA microarray was conducted. Immune-related pathways were markedly altered in ICGN mice kidney as compared with ICR mice. Furthermore, gene expression level of complement component 1, s subcomponent (C1s), whose human homologue has been reported to associate with lupus nephritis, was markedly low in ICGN mice kidney. RNA from renal cortex of 4- and 8-week-old ICGN and ICR mice was extracted and processed for hybridization on Affymetrix microarrays (N=3).

2013-07-31 | E-GEOD-45005 | biostudies-arrayexpress

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