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CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

ABSTRACT: CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

PROVIDER: PRJNA970509 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24474839_1.fastq.gz	Fastqsanger.gz
	SRR24474839_2.fastq.gz	Fastqsanger.gz
	SRR24474840_1.fastq.gz	Fastqsanger.gz
	SRR24474840_2.fastq.gz	Fastqsanger.gz

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CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

Project description:We found that iron chelation restored functional defects in aged HSC, including engraftment potential and platelet bias. To gain molecular insights into iron-dependent mechanism for sustaining HSC identity during aging, we performed Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) with lineage (Lin)− Sca-1+ cKit+ (LSK) cells isolated from aged mice after long-term regimens with iron chelator Deferoxamine or vehicle control.

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