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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

ABSTRACT: TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

PROVIDER: PRJNA989659 | ENA |

REPOSITORIES: ENA

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TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [MeDIP-Seq]

Project description:Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylated modifier TET1 can affect the expressions of key oncogenes or tumor suppressor genes, thus contributing to tumor formation. Nonetheless, how TET1 affects the progression of cervical cancer is yet to be elucidated. In this study, we found that the expression of TET1 was significantly downregulated in cervical cancer tissues. Functionally, TET1 knockdown in cervical cancer cells can promote cell proliferation, migration, invasion, cervical xenograft tumor formation and EMT. On the contrary, its overexpression can reverse the aforementioned processes. Moreover, the autophagy level of cervical cancer cells can be enhanced after TET1 knockdown. Mechanistically, methylated DNA immunoprecipitation (MeDIP)-sequencing and MeDIP quantitative real-time PCR revealed that TET1 mediates the methylation of autophagy promoter regions. These findings suggest that TET1 affects the malignant biological behavior of cervical cancer cells by altering the methylation levels of autophagy genes NKRF and HIST1H2AK, but the specific mechanism needs to be investigated further.

2024-03-13 | GSE236315 | GEO

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

2024-03-13 | GSE236396 | GEO

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

Project description:TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

| PRJNA990741 | ENA

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

Project description:TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy [RNA-seq]

| PRJNA990751 | ENA

MeDIP-chip from clinical cervical tissues in promoters

Project description:Utilizing methylation DNA immunoprecipitation (MeDIP) coupled with promoter tiling arrays, we analyzed the methylation profiles of pooled DNA from human cervical carcinoma and normal cervix

2012-08-06 | GSE33187 | GEO

MeDIP-chip from clinical cervical tissues in promoters

2012-08-05 | E-GEOD-33187 | biostudies-arrayexpress

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-13 | GSE236397 | GEO

MeDIP and hMeDIP-seq of human cervical cancer

Project description:MeDIP and hMeDIP-seq of human cervical cancer

| PRJEB31826 | ENA

MeDIP and hMeDIP-seq of human cervical cancer

Project description:Two cervicitis and four cervical squamous cell carcinoma (two I-IIa and two IIb-IV) were selected from the medical records of the Department of Gynecology of Yuhuangding Hospital from January to July 2017. These six samples were performed MeDIP and hMeDIP-seq to characterize the global pattern of 5mC and 5hmC.

2019-10-04 | E-MTAB-7810 | biostudies-arrayexpress

Venn diagram of PARP1-ChIP, TET1-ChIP and MeDIP in bone marrow-derived human mesenchymal stem cell

Project description:Venn diagram showing overlap in binding sites. Genomic regions from MeDIP analysis (Late > Early) were compared for PARP1 ChIP-seq analysis (Early > Late) and TET1 ChIP-seq analysis (Early > Late). Numbers indicate the number of overlapping genes or regions.

2021-06-25 | GSE178805 | GEO

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