Project description:This SuperSeries is composed of the following subset Series:; GSE6815: Hyperexpression of Mouse Melanotransferrin on LMTK Cell Line; GSE6816: Hyperexpression of Human Melanotransferrin on SK-N-MC Cell Line; GSE6817: Downregulation of Human Melanotransferrin on SK-Mel-28 Cell Line Experiment Overall Design: Refer to individual Series
Project description:Mouse skin cell lines in various stages of tumorigenesis were assayed for transcriptome-wide expression levels. We assessed gene expression levels in mouse skin cell lines representing immortalized keratinocytes, premalignant lesions, malignant squamous cell carcinomas, and malignant squamous cell carcinomas with spindle morphology. These tumors were overwhelmingly driven by Hras mutations. The cells themselves were derived from multiple mouse strains.
Project description:Analysis of global gene expression in a tumor cell line established from a CEA424-Tag mouse and comparison with the expressed gene profile after downregulating the expression of the large T antigen Total RNA obtained from cultured control cell lines and after siRNA mediated downregulation of the SV40 large T antigen