Homo sapiens
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: E-GEOD-6927
PROVIDER: PRJNA99353 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral commensal S. gordonii and the opportunistic commensal F. nucleatum. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral commensal S. gordonii (Sg) or the opportunistic commensal F. nucleatum (Fn). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to commensals, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of health in the mixed bacterial-human ecosystem of the oral cavity.
2009-04-28 | E-GEOD-6927 | biostudies-arrayexpress
Project description:Gingival Epithelial Cell Responses to a Complex Microbiome Comprising Commensal and Opportunistic Oral Microbial Species
| PRJNA113779 | ENA
Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral commensal S. gordonii and the opportunistic commensal F. nucleatum. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Keywords: infection state
2007-06-21 | GSE6927 | GEO
Project description:Gingival Epithelial Cell Transcriptional Responses to Pathogenic Oral Microbial Species.
| PRJNA103635 | ENA
Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by mono- and complex co-culture with oral commensal S. gordonii and pathogenic P. gingivalis. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral commensal S. gordonii (Sg) or the pathogenic P. gingivalis (Pg) as well as co-cultured in mixed cultures of Sg and Pg (Sg+Pg). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to commensals, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of health in the mixed bacterial-human ecosystem of the oral cavity and provides insight on how the degree of complexity of a microbiome influences this balance.
2009-07-18 | E-GEOD-12121 | biostudies-arrayexpress
Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral pathogenic Porphyromonas gingivalis and Aggregatibacter (formerly actinobacillus) actinomycetemcomitans. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral pathogenic P. gingivalis (Pg) or A. actinomycetemcomitans (Aa). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to pathogens, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of microbial disease in the mixed bacterial-human ecosystem of the oral cavity.
2009-04-24 | E-GEOD-9723 | biostudies-arrayexpress
Project description:Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by mono- and complex co-culture with oral commensal S. gordonii and pathogenic P. gingivalis. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Keywords: infection state
2009-07-14 | GSE12121 | GEO
Project description:Understanding the impact of the microbiota on oral mucosal epithelial barriers, particularly within the gingiva, is essential for elucidating the mechanisms underlying oral health and disease. The gingiva exhibits intricate tissue architecture and undergoes dynamic microenvironmental shifts influenced by various factors. Notably, microbial colonization emerges as an early-life factor that plays a significant role in shaping the functional and immunological maturation of the gingival epithelium. This study utilizes spatial transcriptomic analysis to unveil distinct immunological characteristics between the buccal and palatal regions of the murine gingiva, impacting natural alveolar bone loss. Moreover, the analysis identifies a significant influence of the microbiota on the development and function of the junctional epithelium, which faces the oral microbial plaque, offering new insights into neutrophil recruitment to this strategic location. Additionally, the microbiota is found to impact fundamental functions of the gingival epithelium, including proliferation kinetics and barrier sealing. In conclusion, this study emphasizes the crucial role played by the microbiota in regulating gingival barriers and brings attention to its unique influence on specific epithelial regions within the gingiva.
2024-12-18 | GSE269576 | GEO
Project description:Understanding the impact of the microbiota on oral mucosal epithelial barriers, particularly within the gingiva, is essential for elucidating the mechanisms underlying oral health and disease. The gingiva exhibits intricate tissue architecture and undergoes dynamic microenvironmental shifts influenced by various factors. Notably, microbial colonization emerges as an early-life factor that plays a significant role in shaping the functional and immunological maturation of the gingival epithelium. This study utilizes spatial transcriptomic analysis to unveil distinct immunological characteristics between the buccal and palatal regions of the murine gingiva, impacting natural alveolar bone loss. Moreover, the analysis identifies a significant influence of the microbiota on the development and function of the junctional epithelium, which faces the oral microbial plaque, offering new insights into neutrophil recruitment to this strategic location. Additionally, the microbiota is found to impact fundamental functions of the gingival epithelium, including proliferation kinetics and barrier sealing. In conclusion, this study emphasizes the crucial role played by the microbiota in regulating gingival barriers and brings attention to its unique influence on specific epithelial regions within the gingiva.
2024-12-18 | GSE269575 | GEO
Project description:Understanding the impact of the microbiota on oral mucosal epithelial barriers, particularly within the gingiva, is essential for elucidating the mechanisms underlying oral health and disease. The gingiva exhibits intricate tissue architecture and undergoes dynamic microenvironmental shifts influenced by various factors. Notably, microbial colonization emerges as an early-life factor that plays a significant role in shaping the functional and immunological maturation of the gingival epithelium. This study utilizes spatial transcriptomic analysis to unveil distinct immunological characteristics between the buccal and palatal regions of the murine gingiva, impacting natural alveolar bone loss. Moreover, the analysis identifies a significant influence of the microbiota on the development and function of the junctional epithelium, which faces the oral microbial plaque, offering new insights into neutrophil recruitment to this strategic location. Additionally, the microbiota is found to impact fundamental functions of the gingival epithelium, including proliferation kinetics and barrier sealing. In conclusion, this study emphasizes the crucial role played by the microbiota in regulating gingival barriers and brings attention to its unique influence on specific epithelial regions within the gingiva.
2024-12-18 | GSE269171 | GEO