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ProteomicsDetermination of allergen levels, isoforms and their hydroxyproline modifications among peanut genotypes by mass spectrometry
...age proteins, particularly allergens, which make up the peanut seed proteome. A detailed description of the allergenic proteome w...
...ive quantification by mass spectrometry, minor variation of some allergenic proteins was observed but total levels of Ara h 1, 2, 3 and 6 were relatively consistent a...
ORGANISM(S): Arachis Hypogaea (peanut) 
2022-08-11 | PXD028086 | Pride
Food allergy Peanut Hydroxyproline Arachis hypogaea Mass spectrometry 
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ProteomicsIdentification of site-specific incorporation of Kacyl/K*acyl in full-length histones in E. coli and mammalian cells
With the evolution of the PylRS system, we identified the PylRS variants for incorporation of all synthesized Kacyl and Kacyl* in the full-length H3 protein both in E. coli and mammalian cells, which covered the tail domain (eg. K23, K27, K56) as well as the globular domain that are difficult for che...
ORGANISM(S): Homo Sapiens (human) 
2023-03-06 | PXD029504 | Pride
Hek293t Lc-ms/ms Purified proteins E. coli 
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ProteomicsTMT-based proteomics analysis of arachidonic acid (ARA) treated and control oocytes
Arachidonic acid (ARA) treated and control oocytes in 3 replicates were subjected to the 6-plex TMT labeling, HP-RP fractionation, and LC-MS/MS analysis.
ORGANISM(S): Mus Musculus (mouse) 
2022-02-15 | PXD018753 | Pride
Lc-msms Mouse Arachidonic acid Mi Oocytes 
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ProteomicsLC-MS3 analysis of Herc1-knockout mouse MLL/AF9 acute myeloid leukemia cells
Our CRISPR-based pharmacogenomic screening identified the E3 ubiquitin ligase Herc1 as a key modulator of sensitivity to cytarabine (Ara-C) chemotherapy in the MLL/AF9 (MA) mouse AML model both in vitro and in vivo. To identify the intracellular proteins whose abundance is modulated by Herc1, we perfor...
ORGANISM(S): Mus Musculus (mouse) 
2024-08-08 | PXD054402 | Pride
Mouse Herc1 Acute myeloid leukemia Lc-ms3 
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TranscriptomicsTranscriptome Sequencing (RNA-seq) of Ara-C Resistant Murine AML Cell Lines Identifies Mechanisms of Resistance
An RNA-seq study of altered gene expression and mutations in Ara-C resistant acute myeloid leukemia murine cell lines. The analysis of the RNA-seq data led to the identification of a large deletion within the Dck coding sequence of the B117H cell line, which produced an alternatively processed form ...
ORGANISM(S): Mus musculus 
2014-08-13 | E-GEOD-47454 | biostudies-arrayexpress
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TranscriptomicsTranscription profiling of two highly Ara-C resistant cell lines, B117H and B140H and two Ara-C sensitive parental cell lines, B117P and B140P to study altered gene expression in acute myeloid leukemia cell lines.
A microarray study of altered gene expression in acute myeloid leukemia cell lines Experiment Overall Design: Two highly Ara-C resistant cell lines, B117H and B140H were derived from Ara-C sensitive parental cell lines, B117P and B140P. Variations in gene expression between these resistant/sensitive s...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2788 | biostudies-arrayexpress
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TranscriptomicsALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia
MLL-rearranged acute myeloid leukemia (AML) remains a fatal disease with a high rate of relapse and therapeutic failure...
...showed a significantly higher sensitivity to the standard chemotherapeutic agents, i.e., doxorubicin (DOX) and cytarabine (Ara-C). The drug-sensitizing role of Alox5 was further confirmed in human and murine MLL-rearranged AML cell models in vitro, as well as in the in vivo MLL-rearranged AML BMT model coupled with treatment of “5+3” (i.e. DOX plus Ara-C) regimen. Our RNA-seq analysis showed...
ORGANISM(S): Mus musculus 
2017-06-09 | GSE94840 | GEO
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ProteomicsKininogen–Nitric Oxide Signaling at Nearby Non-excited Acupoints After Long-term Stimulation
...nt is based on acupoint stimulation; however, the biological basis is not understood. We stimulated one acupoint with catgut embedding (CEP) for 8 weeks and then used isobaric tags for relative and absolute quantitation to screen proteins with altered expression in adjacent acupoints of Sprague Dawle...
ORGANISM(S): Rattus Norvegicus (rat) 
2022-02-16 | PXD024018 | Pride
Kng–nitric oxide signaling pathway，acupoints， long-term stimulation， 
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ProteomicsGlobal Proteomic Profiling of Pediatric AML: A Pilot Study
Acute Myeloid Leukemia (AML) is a heterogeneous disease with several recurrent cytogenetic abnormalities. Despite genomics and transcriptomics profiling efforts to understand AML’s heterogeneity, studies focused on the proteomic profiles associated with pediatric AML cytogenetic features remain limit...
ORGANISM(S): Homo Sapiens (human) 
2023-09-26 | PXD043982 | Pride
Pediatrics acute myeloid leukemia Transcriptomics Tandem mass tag Leukemic cells Untargeted labeled proteomics 
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Proteomics,MultiomicsArabidopsis proteomic tissue atlas
Qualitative and quantitative atlas of the transcriptomes, proteomes and phosphoproteomes of 30 tissues of the model plant Arabidopsis. We describe how many genes were detected as proteins (>18,000), where they are expressed, in which approximate quantities (>6 logs dynamic range) and to what extent the...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2020-01-10 | PXD013868 | Pride
Arabidopsis Proteome Phosphoproteome Tissue atlas 
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