Sort   by:  
 Page size 
0
ProteomicsER-associated degradation of Eag1 potassium channels by the RING E3 ubiquitin ligase MKRN1: the presence of a dual ubiquitination system
Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K+ channel are associated with neurodevelopmental diseases, indicating ...
...ty controls of Eag1, MKRN1 is exclusively responsible for the early stage of Eag1 maturation at the ER. We further demonstrated that both CUL7 and MKRN1 contribute to protein quality control of additional disease-causing Eag1 mutants associated with defective protein homeostasis. Our data suggest that the presence of this dual ubiquitination system differentially maintains Eag1 protein homeostasis and may ensure efficient removal of disease-associated misfolded Eag1 mutant channels.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD023984 | Pride
Ring e3 Mkrn1 
0
ProteomicsGlobal Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice
...ing various biological processes. However, comprehensively phosphoproteomic profiling in the termination of liver regeneration (LR) is still missing. Here, we used TMT l...
...503 phosphorylation sites in 358 proteins were down-regulated. The differentially phosphorylated proteins were further classified according to their biological process, cellular components, m...
ORGANISM(S): Mus Musculus (mouse) 
2020-03-04 | PXD011374 | Pride
partial hepatectomy Phosphorylation Phosphorylation  partial hepatectomy  liver regeneration  metabolic reprogramming liver regeneration metabolic reprogramming 
0
ProteomicsNebulette reinforces podocyte structural integrity by linking actin and vimentin filaments
One of the key aspects of the specialized podocyte morphology is the segregation and organization o...
...tein nebulette as a unique component of the podocyte cytoskeleton that correlates strongly with glomerular function.
ORGANISM(S): Rattus Norvegicus (rat) 
2022-02-15 | PXD016629 | Pride
F-actin Nephropathy Podocytes Nebulette 
0
ProteomicsWhole-Genome Wide Quantitative Proteomics Studies Revealed Tissue-Specific Expression and Phosphorylation of Regulatory Proteins in Arabidopsis
Organogenesis in plants occurs during all stages of the life cycle. Although previous studies have identified many genes important for either ve...
...ewly discovered, including 275 showing differential expression patterns, providing possible candidates for functional studies or molecular markers. In addition, more phosphorylated proteins were identified in reproductive stages (1,149) than in the vegetative process (995). 701 of the proteins differentially phosphorylated between flowers and leaves were predicted to localize to the nucleus, including 22 transcription factors. Moreover, phosphorylation of CDPK6 and MAPK6 and their interacting proteins, were enriched in reproductive tissues. Over...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2021-09-09 | PXD019691 | Pride
Phosphorylation Quantitative proteomics Arabidopsis 
0
ProteomicsReceptor Tyrosine Kinase Inhibitors Block proliferation of coronavirus mainly through p38 mitogen-activated protein kinase pathways
...(CoVs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, for which no approved therapeutics are available so far. Here A9, a receptor tyrosine kinas...
...exhibited potent antiviral activity against various coronavirus replication, including MHV, PEDV and FIPV. We further investigated the mechanism of action of A9 against TGEV infection in vitro with compa...
ORGANISM(S): Sus Scrofa (pig) 
2020-05-26 | PXD010685 | Pride
Transmissible gastroenteritis virus Emerging coronaviruses Lc–ms/ms analysis. Rtkis 
0
ProteomicsHuman POP analysis - Proteomics of Uterosacral Ligament Connective Tissue from Women With and Without Pelvic Organ Prolapse
Purpose: Damage to the uterosacral ligaments is an important contributor to uterine and vaginal prolapse. The aim of this study was to identify differentially expressed proteins in the uterosacral ligaments of...
...ay analysis demonstrated 14 differentially expressed proteins that were associated with "Connective Tissue Function". Among them, fibromodulin(FMOD), Collagen alpha-1 (XIV) chain(COL14A1), Calponin-1 (CNN-1), Tenascin (TNC), and Galectin-1(LGALS1 appeared most likely to play a role in the etiology of pelvic organ prolapse. Conclusions and clinical relevence: We identified at least 6 proteins not previously associated with the pathogenesis of pelvic organ prolapse with biologic functions that suggest a plausible relationship to the disorder. These results may be helpful for furthering our understanding o...
ORGANISM(S): Homo Sapiens (human) 
2018-12-10 | PXD011467 | Pride
uterosacral ligament Ingenuity pathway analysis itraq analysis Ingenuity pathway analysis  itraq analysis  pelvic organ prolapse  uterosacral ligament Reproductive system pelvic organ prolapse 
0
ProteomicsHoneybee Brain LC-MS/MS - Proteomics Reveals the Molecular Underpinnings of Stronger Learning and Memory in Eastern Compared to Western Beess
Honeybee brain has distHoneybee brain has distinct anatomical and functional regions, knowledge on molecular underpinnings of sub-organ to achieve the distinct neural function and the difference between the eastern and western honeybees are still missing. Here, the proteomes of three sub-organs of eas...
ORGANISM(S): Apis Mellifera (honeybee) 
2017-12-04 | PXD007091 | Pride
Honeybee mushroom bodies antennal lobes optical lobes proteome 
0
ProteomicsSingle-cell and Spatial Architecture of Primary Liver Cancer
Using single-cell RNA sequencing, spatial transcriptomic and bulk multi-omics, we elaborated a molecular architecture of 3 PLC types, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular-cholangiocarcinoma (CHC) from a high-resolution perspective.
ORGANISM(S): Homo Sapiens (human) 
2024-01-26 | PXD044778 | Pride
Primary liver cancer Spatial transcriptomics Combined hepatocellular-cholangiocarcinoma Intrahepatic cholangiocarcinoma Hepatocellular carcinoma Multi-omics Single-cell rna-seq 
0
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
...inib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a reconstru...
ORGANISM(S): Homo Sapiens (human) 
2018-10-26 | PXD005734 | Pride
Lc-ms/ms Activity-based protein profiling Ibrutinib B-cell cancers 
0
Proteomicshoneybee brain - Brain Membrane Proteome and Phosphoproteome Reveal Molecular Basis Associating with Nursing and Foraging Behaviors of Honeybee Workers
he brain is a vital organ in regulating complex social behaviors of honeybees including learning and memory. Knowledge of how brain membrane proteins and their phosphorylation underlie the age-related behavioral polyethism is still lacking. We presented the first comprehensive profiling and compariso...
ORGANISM(S): Apis Mellifera (honeybee) 
2017-09-11 | PXD006823 | Pride
Brain Honeybee Membrane Proteome Phosphoproteome 
Sort   by:  
 Page size