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ProteomicsComparative proteomic analysis revealed the differential responses to novel duck reovirus infection in the bursa of Fabricius of Cairna moschata
Duck reovirus (DRV) is well-studied aquatic bird virus belonging to the Orthoreovirus genus of the Reoviridae family. The bursa of Fabricius is an immunologically organ against virus invasion. However, the responses of the bursa of Fabricius of Cairna moschata to DRV infection are largely unknown. To...
ORGANISM(S): Cairina Moschata 
2022-08-12 | PXD025093 | Pride
the bursa of fabricius reovirus differential accumulated protein Cairna moschata Cairna moschata  differential accumulated protein  reovirus  proteomic analysis  the bursa of fabricius proteomic analysis 
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ProteomicsAPEX1 alters the phospho-landscape of SKOV3 cells
APEX1 overexpression and knockdown cell lines were established based on SKOV3 cell line. Lable-free quantitative phosphoproteomics was done to evaluate the impact of APEX1 on cellular phosphoproteomics
ORGANISM(S): Homo Sapiens (human) 
2024-05-22 | PXD040041 | Pride
phosphoproteomics Lc-msms Lc-msms  phosphoproteomics 
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ProteomicsSuccinylome analysis reveals the involvement of lysine succinylation in extreme resistance of Deinococcus radiodurans
Increasing evidences showing that succinylation of lysine residue mainly regulates enzymes involved in the carbon metabolism pathway, both in prokaryotic and eukaryotic cells. Deinococcus radiodurans is one of the most radioresistant organisms on earth, which is famous for its robust resistance. A ma...
ORGANISM(S): Deinococcus Radiodurans 
2021-04-26 | PXD012149 | Pride
posttranslational modification nucleic acid binding succinylation dna repair Succinylome Succinylome  succinylation  dna repair  nucleic acid binding  posttranslational modification 
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ProteomicsComparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata
Duck reovirus (DRV) is an typical aquatic bird pathogen belonging to the Orthoreovirus genus of the Reoviridae family. Re...
... quantified. The differential expressed proteins (DEPs) between the control and infected liver cells displayed various biological functions and diverse subcellular localizations. Among the DEPs, most of the metabolism-related proteins were down-regulated, suggesting a decrease in the basal metabolisms under C/NDRV infections. Several important factors in the complement, coagulation and fibrinolytic systems were significantly up-regulated by C/NDRV infec...
ORGANISM(S): Cairina Moschata 
2018-10-22 | PXD008623 | Pride
Cairna moschata Cairna moschata  differential expressed protein  duck reovirus  proteome  serine protease serine protease differential expressed protein duck reovirus proteome 
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ProteomicsOvarian cancer cell line LC-MS-MS
A2780-DR cells are cisplatin resistance compared to A2780. H19 knockdown in A2780-DR cells resulted in recovery of cisplatin sensitivity in vitro and in vivo. To demonstrate how H19 contributes to cisplatin-resistance in ovarian cancer, proteomic analysis was carried out on A2780, A2780-DR, A2780-DR/...
ORGANISM(S): Homo Sapiens (human) 
2018-10-25 | PXD003252 | Pride
lc-ms-ms Ovarian cancer  cisplatin resistance  lc-ms-ms cisplatin resistance Ovarian cancer 
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ProteomicsBlood coagulation and complement activation interact to increase disease activity in systemic lupus erythematosus and coagulation D-Dimer combined with complement C4 is a biomarker of lupus activity
This study was conducted to (1) find deregulation of certain pathways in SLE at multi-omics levels; (2) evaluate the associations among blood coagulation, complement activation, inflammatory responses and SLE disease severity; (3) develop biomarkers to facilitate better the assessment of the likeliho...
ORGANISM(S): Homo Sapiens (human) 
2018-10-27 | PXD004443 | Pride
Systemic lupus erythematosus blood coagulation itraq Systemic lupus erythematosus  blood coagulation itraq 
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ProteomicsMycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Interferon (IFN)-γ-producing CD8+ T cells are involved in control of Mycobacterium tuberculosis (Mtb) infection, in part by promoting antimicrobial activities of macrophages. Whether Mtb counters these responses, particularly during the hypoxic conditions that arise within granulomas during infection...
ORGANISM(S): Mycobacterium Tuberculosis Ofxr-32 
2024-08-10 | PXD050258 | Pride
Mycobacterium tuberculosis  d-serine  rv0884c  wdr24  mtorc1  cd8+ t cell Mycobacterium tuberculosis d-serine rv0884c wdr24 cd8+ t cell mtorc1 
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ProteomicsDynamic phosphoproteomics of BRS3 activation reveals Hippo signaling pathway for cell migration
...n receptor subtype-3 (BRS3) is an orphan G-protein coupled receptor (GPCR) that involved in a range of pathological and physiological processes, while its biological functions and underlying regulatory mechanisms remain largely unknown. Quantitative phosphoproteomics approach was employed in this stud...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD035666 | Pride
Phosphoproteomics Signaling transductions Gpcr Hippo signaling pathway Cell migration 
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UnknownPrediction model of random forest for the risk of hyperuricemia in a Chinese basic health checkup test.
Not available
S-EPMC8026814 | biostudies-literature
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UnknownHyperuricemia prevalence and its association with metabolic disorders: a multicenter retrospective real-world study in China.
Not available
S-EPMC8576711 | biostudies-literature
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