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TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous ...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
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UnknownIron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1.
Not available
S-EPMC6815829 | biostudies-literature
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UnknownCoexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.
Not available
S-EPMC5095759 | biostudies-literature
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UnknownNovel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer.
Not available
S-EPMC3976221 | biostudies-literature
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UnknownRUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.
Not available
S-EPMC3952363 | biostudies-literature
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UnknownSpecific phosphorylation of microtubule-associated protein 2c by extracellular signal-regulated kinase reduces interactions at its Pro-rich regions.
Not available
S-EPMC9520037 | biostudies-literature
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Unknown?-Thalassemia due to intronic LINE-1 insertion in the ?-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the ?-globin(L1) allele.
Not available
S-EPMC4993193 | biostudies-literature
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UnknownOxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia.
Not available
S-EPMC7768356 | biostudies-literature
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UnknownDifferential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells.
Not available
S-EPMC4096297 | biostudies-literature
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UnknownHIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.
Not available
S-EPMC4833890 | biostudies-literature
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