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Proteomics,MultiomicsIn vivo DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approve...
ORGANISM(S): Homo Sapiens (human) 
2018-01-31 | PXD008546 | Pride
Ddr1 tyrosine kinase Signalling Metastatic colorectal cancer 
0
Proteomics,MultiomicsIn vitro DDR1 signalling - Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer
The clinical management of metastatic colorectal cancer (mCRC) faces major challenges. For instance, patients harbouring oncogenic mutations in RAS signalling do not respond to anti-EGFR targeted treatment. Therefore, RAS-independent therapies are needed. Interestingly nilotinib, a clinically approve...
ORGANISM(S): Homo Sapiens (human) 
2018-01-31 | PXD008582 | Pride
Ddr1 tyrosine kinase Signalling Metastatic colorectal cancer 
0
Genomics,MultiomicsFramingham Cohort

<b>Startup of Framingham Heart Study. Cardiovascular disease (CVD) is the leading cause of death and serious illness in the United States. In 1948, the Framingham Heart Study (FHS) -- under the direction of the National Heart Institute (now known as the National Heart, Lung, and Blood Institut...

phs000007.v17.p6 | EGA
1K
Other,MultiomicsWellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute (WTSI), Hinxton, Cambridge, UK is a not-for-profit research organisation and a world famous Genome Centre dedicated to the sequencing and functional analysis of genomes. The Sanger Institute underpins biological and medical research worldwide through large-scale an...
EGAO00000000020 | EGA
0
GenomicsCIDR Whole Exome Sequencing in Joubert Syndrome

The purpose of this study is to identify new genetic causes of neurodevelopmental diseases (NDDs) in the Joubert syndrome (JS) spectrum. Joubert syndrome is a recessive disease characterized by cerebellar vermis hypoplasia. Our currently funded NINDS award entitled "Molecular characterization of J...

phs000382.v1.p1 | EGA
0
UnknownSearch for heavy particles decaying into top-quark pairs using lepton-plus-jets events in proton-proton collisions at s=13   TeV with the ATLAS detector.
Not available
S-EPMC6191020 | biostudies-other
0
UnknownODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing.
Not available
S-EPMC7809782 | biostudies-literature
0
UnknownNeuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial.
Not available
S-EPMC7616346 | biostudies-literature
0
UnknownCorrection to: Risdiplam in Patients Previously Treated with Other Therapies for Spinal Muscular Atrophy: An Interim Analysis from the JEWELFISH Study.
Not available
S-EPMC10444665 | biostudies-literature
0
UnknownHACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.
Not available
S-EPMC3656887 | biostudies-other
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