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ProteomicsThe Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
In eukaryotes, trimethylation of lysine 9 on histone H3 (H3K9) is associated with transcriptional silencin...
...In drosophila ovaries, this heterochromatic repressive mark is thought to be deposited by SetDB1 on TE genomic loci after the initial recognition of nascent transcripts by PIWI-interacting RNAs (piRNAs) loaded on the Piwi protein. Here, we show that the nucleosome remodeler Mi-2, in complex with its partner MEP-1, forms a subunit that is transiently associated, in a MEP-1 C-terminus-dependent manner, with known Piwi interactors, including a recently reported SUM...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2020-07-21 | PXD018749 | Pride
Mep-1 Mi-2 Rpd3 Gtsf1 
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ProteomicsPlasma-derived extracellular vesicles contain predictive biomarkers and potential therapeutic targets for myocardial ischemic injury
...ion (MI), an undesirable clinical outcome of coronary artery disease (CAD), triggers a potent inflam...
... by damaged cardiac cells, which is necessary for myocardial healing. However, when in excess, causes pathological tissue re...
ORGANISM(S): Homo Sapiens (human) 
2016-05-31 | PXD002950 | Pride
plasma or serum analysis extracellular vesicles exosomes label-free quantification Cardiovascular disease Cardiovascular disease  exosomes  label-free quantification  plasma or serum analysis  biomarker: diagnostic  extracellular vesicles biomarker: diagnostic 
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ProteomicsWoundhealing proteomic profile
Glycoproteomics was performed on plasma collected from mice 3 days after biopsy punch wound healing and 3 days after myocardial infarction (MI) wound healing.
ORGANISM(S): Mus Musculus (mouse) 
2022-04-01 | PXD011790 | Pride
Heart Woundhealing Mi 
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TranscriptomicsThe Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription
Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosomes ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-08 | E-GEOD-46649 | biostudies-arrayexpress
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ProteomicsProteomic analysis identifies the potential effects of trichostatin A and bone marrow-derived dendritic cells on NIH3T3 cells under oxygen–glucose deprivation conditions
Fibroblasts usually mediate acute wound healing and long-term tissue remodeling with scarring in tissue injury. In myocardial infarction (MI), following a prolonged lack of oxygen supply, necrotized cardiomyocytes become replaced by secreted extracellular matrix proteins produced by fibroblasts. Dendr...
ORGANISM(S): Mus Musculus (mouse) 
2024-05-21 | PXD021469 | Pride
bmdcs Tsa fatty acid metabolism Tsa  bmdcs  nih3t3 cells  fatty acid metabolism nih3t3 cells 
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ProteomicsAnalysis of the psychrophilic fungus Mrakia psychrophila using shotgun proteomics
Comprehensive and quantitative information of the psychrophile proteome is an important source for unde...
...uantitatively evaluate its protein abundance changes in response to three different temperatures. With optimized procedures of isob...
ORGANISM(S): Mrakia Psychrophila 
2016-12-07 | PXD004881 | Pride
Fungi Psychrophilic Itraq 
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ProteomicsCHIP phosphorylation regulates proteostasis
Proteotoxicity from insufficient clearance of misfolded/damaged proteins underlies many diseases. Carboxyl terminus of Hsc70-interacting protein (CHIP) is an important regulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing damaged proteins towards proteas...
ORGANISM(S): Rattus Norvegicus (rat) 
2021-09-09 | PXD021531 | Pride
Rat myocyctes phosphorylation chip pkg cardiac ischemia 
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GenomicsSTAMPEED: Myocardial Infarction Genetics Consortium (MIGen)

Myocardial infarction (MI) is a common complex disease and the leading cause of death and disability worldwide. The genetic basis of this disease is largely unknown. It has been thought that early-onset MI events would have a substantially greater heritability, thus making DNA collections with ...

phs000294.v1.p1 | EGA
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TranscriptomicsGenome-wide profiling of gene expression under electro-acupuncture treatment on MI heart in rats
Purpose: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI). In order to elucidate the potential mechanisms, RNA-seq by next generation s...
...l with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. Results: Using an optimized data analysis workflow, we mapped about 25 million sequence reads per sample to the mouse genome (UCSC RN4) and identified 121,233, 178,242, 161,880 transcripts in the Control, MI and EA rats with TopHat and Cufflinks workflow respectively. Approximately 32% and 22% of the transcripts showed differential expression between the Control and MI, MI and EA respectively with a fold change ≥2.0. Conclusions: Our results f...
ORGANISM(S): Rattus norvegicus 
2016-03-21 | E-GEOD-54132 | biostudies-arrayexpress
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ProteomicsTransfer of Alarmins from Neutrophils to Platelets after Acute Myocardial Infarction
Platelets are central to the pathophysiology of myocardial infarction (MI). How the platelet proteome is altered during MI is unknown. We sought to describe ch...
...utrophils were co-incubated under quiescent and TRAP-6 activated conditions, release of S100A8 from neutrophils resulted in uptake of S100A8 by platelets. Leukocyte-to-platelet protein transfer, rather than protein synthesis, may occur in a thromboinflammatory environment such as STEMI, representing a potential new contributor in the innate immune pathogenesis of STEMI.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD024186 | Pride
Human Cellular hemostasis and platelets Orbitrap fusion lumos Atherosclerosis and ischemic disease 
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