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ProteomicsA Proteomic Chronology of Gene Expression through the Cell Cycle in Human Myeloid Leukemia Cells.
...is of cellular protein and RNA levels with unprecedented depth and sensitivity, allowing for an unbiased re-evaluation of gene regulation during fundamental biological processes. Here, we have chronicled the dynamics of protein and mRNA expression levels across a minimally perturbed cell cycle in hum...
ORGANISM(S): Homo Sapiens (human) 
2014-03-12 | PXD000678 | Pride
Hsax Human Nb4 Cell cycle Fasp 
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ProteomicsCyanobacterial proteome mapping reveals distinct compartment organisation and metabolism dispersed throughout the cell
Cyanobacteria are complex prokaryotes, incorporating a Gram-negative cell wall and internal thylakoid membranes (T...
...signed to six specific subcellular regions. Proteins involved in energy generation localised to TMs. The majority of transporters, with the exception of the TM localised copper importer CtaA, resided in the plasma membrane (PM). Most metabolic enzymes are soluble although numerous pathways terminated in the TM (notably those involved in peptidoglycan monomer, N...
ORGANISM(S): Bacteria Synechocystis Sp. Pcc 6803 
2019-10-31 | PXD014662 | Pride
Spatial proteomics Cyanobacteria Synechocystis Lopit 
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ProteomicsComparative quantitative proteomic analysis of Arabidopsis thylakoid membranes from plants grown under low, moderate and high illumination. Effects of stn7 and tap38 mutations.
Plants grown under different illumination levels undergo a long-term acclimation response (LTR) resulting in differences in their leaf morphology and chloroplast protein composition to maximise their growth. At the proteomic level, LTR involves modulating the stoichiometry of photosynthetic complexes...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2023-03-30 | PXD037358 | Pride
Arabidopsis thaliana Photosystem Light harvesting complex Tap38 Electron transfer. Light acclimation Thylakoid Stn7 
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ProteomicsDiscovery of drugs to treat cytokine storm-induced cardiac dysfunction
SARS-CoV2 infection leads to cardiac injury and dysfunction in 20-30% of hospitalized patients and higher rates of mortality in patients with pre-existing cardiovascular disease. Inflammatory factors released as part of the 'cytokine storm' are thought to play a critical role in cardiac dysfunction i...
ORGANISM(S): Homo Sapiens (human) 
2022-02-21 | PXD020994 | Pride
Heart Phosphoproteomics Covid-19 Easyphos Sars-cov2 Cytokine storm Cardiac organoids 
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ProteomicsSCFCyclin F targets the metabolic protein Sirtuin 5 for ubiquitination
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. H...
ORGANISM(S): Homo Sapiens (human) 
2020-11-17 | PXD019396 | JPOST Repository
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UnknownThe atzB gene of Pseudomonas sp. strain ADP encodes the second enzyme of a novel atrazine degradation pathway.
Not available
S-EPMC168384 | biostudies-other
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UnknownMotor-Driven Restructuring of Cytoskeleton Composites Leads to Tunable Time-Varying Elasticity.
Not available
S-EPMC9239751 | biostudies-literature
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UnknownAtrazine chlorohydrolase from Pseudomonas sp. strain ADP: gene sequence, enzyme purification, and protein characterization.
Not available
S-EPMC178272 | biostudies-other
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MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

m>Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stress...

2022-02-23 | MTBLS318 | MetaboLights
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UnknownEvaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans.
Not available
S-EPMC6739150 | biostudies-literature
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