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ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization sta...
ORGANISM(S): Homo Sapiens (human) 
2020-10-19 | PXD015431 | Pride
Adam17 Iodotmt Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization 
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ProteomicsMeta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients
The relationship between the microbial changes with clinical-pathological outcomes are still far from being conclusive. Herein, we investigate the ability of metagenomics (MG) and metaproteomics (MP) saliva data in distinguishing C, L0 and L1 patients. For that, we combined two strategies using MG an...
ORGANISM(S): Homo Sapiens (human) 
2022-11-09 | PXD022859 | Pride
Oral microbiome Oral squamous cell carcinoma Oral cancer diagnosis and prognosis Saliva Mass spectrometry 
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ProteomicsThermus filiformis proteome analysis
Proteome analysis of thermophilic bacteria Thermus filiformis cultivated in different temperatures (63, 70 and 77 Celsius degree)
ORGANISM(S): Thermus Filiformis (ncbitaxon:276) 
2016-04-16 | MSV000079653 | MassIVE
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ProteomicsComparative genomics reveals high biological diversity and specific adaptations in the fungal genus Aspergillus
The project compares the genomes of multiple Aspergillus species. In particular, the genes involved in the degradation of plant-derived biomass have been analyzed. As well, the extracellular proteins produced by the fungi during the utilization of sugar beet pulp and wheat bran were examined by LC-MS...
ORGANISM(S): Aspergillus Wentii Aspergillus Foetidus Var. Acidus Aspergillus Versicolor Aspergillus Zonatus Aspergillus Aculeatus Atcc 16872 Aspergillus Carbonarius Item 5010 Aspergillus Tubingensis Aspergillus Brasiliensis Aspergillus Sydowii 
2018-10-26 | PXD005563 | Pride
Biomass degradation Lc-ms/ms Extracellular proteins Aspergilli 
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ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neoplas...
ORGANISM(S): Homo Sapiens (human) 
2018-09-10 | PXD007232 | Pride
Oscc Ffpe Lc-ms/ms 
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ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1
We have previously shown that Thioredoxin-1 (Trx-1) binds to the cytoplasmic domain of ADAM17 (ADAM17cyto), A Disintegrin And Metalloprotease 17, and that the destabilization in their interface of interaction favors the Trx-1 dimeric and inactive state. These studies opened the question of whether AD...
ORGANISM(S): Homo Sapiens 
2021-03-12 | PXD020016 | panorama
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