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ProteomicsThe leader peptide peTrpL forms antibiotic-containing ribonucleoprotein complexes for posttranscriptional regulation of multiresistance genes
Bacterial ribosome-dependent attenuators are widespread posttranscriptional regulators. They harbour small upstream ORFs (uORFs) encoding leader peptides, for which no functions in trans are known yet. In the soil-dwelling plant symbiont Sinorhizobium meliloti, the tryptophan biosynthesis gene trpE(G...
ORGANISM(S): Rhizobium Meliloti (ensifer Meliloti) (sinorhizobium Meliloti) 
2020-05-19 | PXD018342 | Pride
Multiresistance Quantification Small proteins Attenuator Posttranscriptional regulation Sinorhizobium meliloti 
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ProteomicsBacterial stigmasterol degradation involving radical flavin delta-24 desaturase and molybdenum-dependent C26 hydroxylase
Sterols are ubiquitous membrane constituents that persist to a large extent in the environment due to their water insolubility and chemical inertness. Recently, an oxygenase-independent sterol degradation pathway was discovered in a cholesterol-grown denitrifying bacterium Sterolibacterium (S.) denit...
ORGANISM(S): Sterolibacterium Denitrificans 
2024-05-21 | PXD048763 | Pride
Flavin radical enzyme Stigmasterol Steroid degradation Anaerobic metabolism Desaturasem Molybdenum enzyme 
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TranscriptomicsTranscription profiling of Legionella pneumophila wild type vs fleR mutant at OD 3.3
Comparison of gene expressions of Legionella pneumophila wide types and fleR mutants. Liquid ...
... log; test - student test with varmixt; filtering - spot saturation detection. Axon for scanning. Contact: Christian Weber and Tobias Sahr
ORGANISM(S): Legionella pneumophila 
2009-11-24 | E-MTAB-163 | biostudies-arrayexpress
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ProteomicsAnalysis of sectreted proteins from breast cancer cells
Analysis of sectreted proteins from pure media, LX and Heps breast cancer cells grown in conditioned media. All samples were prepared in biological triplicates.
ORGANISM(S): Homo Sapiens (human) 
2021-06-28 | PXD015426 | Pride
Lc-ms Conditioned media Secretome 
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ProteomicsIKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
Quantitative proteomic profiling of TPCA-1-treated bone marrow-derived macrophages stimulated with TNF-α (50 ng/mL) for 24 h. TNF-α was used as an endogenous pro-inflammatory stimulus and inducer of sterile inflammation.
ORGANISM(S): Mus Musculus (mouse) 
2023-03-11 | PXD036118 | Pride
Tpca-1 Tnf-α Ikkβ Macrophages 
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UnknownExtracellular vesicles are associated with C-reactive protein in sepsis.
Not available
S-EPMC7997920 | biostudies-literature
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ProteomicsMHCquant: Automated and reproducible data analysis for immunopeptidomics
Personalized multi-peptide vaccines are currently being discussed intensively for tumor immunotherapy. In order to find epitopes - short, immunogenic peptides - suitable to elicit an immune response, human leukocyte antigen-presented peptides from cancer tissue samples are purified using immunoaffini...
ORGANISM(S): Homo Sapiens (human) 
2019-10-14 | PXD011628 | Pride
Human Benchmark Mhc 
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UnknownPolystyrene-Divinylbenzene-Based Adsorbents Reduce Endothelial Activation and Monocyte Adhesion Under Septic Conditions in a Pore Size-Dependent Manner.
Not available
S-EPMC5023745 | biostudies-literature
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ProteomicsThe amino acid homoarginine inhibits atherogenesis by modulating T-cell function
Rational: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid homoarginine (HA) is a robust biomarker for cardiovascular outcome and mortality with high levels being protective. However, the underlying molecular mechanism remains elusive. Objec...
ORGANISM(S): Mus Musculus (mouse) 
2023-01-30 | PXD023960 | Pride
Homoarginine Atherosclerosis Amino acids Actin cytoskeleton T cells 
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ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mela...
ORGANISM(S): Homo Sapiens (human) 
2017-04-06 | PXD004894 | Pride
Neoantigens Immunopeptidomics Lc-ms/ms Cancer antigens 
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