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E-MTAB-3645

ABSTRACT: Analysis of gene expression changes in response to hypoxia and/or cisplatin in A2780 and A2780cis cells

PROVIDER: E-MTAB-3645 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-MTAB-3645-analysis-methods.tsv	Tabular
	E-MTAB-3645-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-3645-configuration.xml	Xml
	E-MTAB-3645-percentile-ranks.tsv	Tabular
	E-MTAB-3645.condensed-sdrf.tsv	Tabular

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Analysis of gene expression changes in response to hypoxia and/or cisplatin in A2780 and A2780cis cells

Project description:The aim of this experiment was to evaluate the changes in gene expression in response to hypoxia and/or cisplatin in an ovarian cancer cell line model. A2780 (cisplatin-sensitive) and A2780cis (cisplatin-resistant) cell lines were treated with cisplatin in normoxia or hypoxia (0.5% O2) for 72 hours. RNA was extracted from three independent biological replicates for each condition: A2780 (normoxia, untreated); A2780 (hypoxia, untreated); A2780 (normoxia, cisplatin); A2780cis (hypoxia, cisplatin), A2780cis (normoxia, untreated); A2780cis (hypoxia, untreated); A2780cis (normoxia, cisplatin); A2780cis (hypoxia, cisplatin) and interrogated on Affymetrix Human Gene ST 1.0 arrays.

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