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E-MTAB-5388

ABSTRACT: Microarray analysis of the Lysosome-dependent activation of human dendritic cells by the vaccine adjuvant QS-21.

PROVIDER: E-MTAB-5388 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-MTAB-5388-analysis-methods.tsv	Tabular
	E-MTAB-5388-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-5388-configuration.xml	Xml
	E-MTAB-5388-percentile-ranks.tsv	Tabular
	E-MTAB-5388.condensed-sdrf.tsv	Tabular

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Project description:QS-21 is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified antigens, yet how it activates immune cells is largely unknown. Here, QS-21 (or DQ) directly activated human monocyte-derived dendritic cells (moDCs) and promoted a pro-inflammatory transcriptional program.

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