Dataset Information

Mandlik2013 - Synthetic circuit of IPC synthase in Leishmania

ABSTRACT: Mandlik2012 - Synthetic circuit of IPC synthase in Leishmania A genetic circuit for the targeted enzyme inositol phosphorylceramide (IPC) synthase belonging to the protozoan parasite Leishmania is constructed by Mandlik et al. (2013). This model is described in the article: Synthetic circuit of inositol phosphorylceramide synthase in Leishmania: a chemical biology approach Mandlik V., Limbachiya D., Shinde S., Mol M, S., Singh, S. J Chem Biol. January 2013 Abstract: Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge, there are no literature reports for the synthetic circuit construction for protozoan parasites. This paper describes the construction of genetic circuit for the targeted enzyme inositol phosphorylceramide synthase belonging to the protozoan parasite Leishmania. To explore the dynamic nature of the circuit designed, simulation was done followed by circuit validation by qualitative and quantitative approaches. The genetic circuit designed for inositol phosphorylceramide synthase (Biomodels Database—MODEL1208030000) shows responsiveness, oscillatory and bistable behavior, together with intrinsic robustness. This model is hosted on BioModels Database and identified by: MODEL1208030000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

DISEASE(S): Leishmaniasis

SUBMITTER: Vijayalakshmi Chelliah

PROVIDER: MODEL1208030000 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1208030000?filename=MODEL1208030000-biopax2.owl	Owl
	MODEL1208030000?filename=MODEL1208030000-biopax3.owl	Owl
	MODEL1208030000?filename=MODEL1208030000.m	Other
	MODEL1208030000?filename=MODEL1208030000.pdf	Pdf
	MODEL1208030000?filename=MODEL1208030000.png	Other

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Publications

Synthetic circuit of inositol phosphorylceramide synthase in Leishmania : a chemical biology approach.

Mandlik Vineetha V Limbachiya Dixita D Shinde Sonali S Mol Milsee M Singh Shailza S

Journal of chemical biology 20130103 2

Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge, there are no literature reports for the synthetic circuit construction for protozoan parasites. This paper describes the construction of genetic circuit for the targete ...[more]

PMID: 24386012

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