Models

Dataset Information

0

Sier2017_estrogen_PBPK_GSMN


ABSTRACT: Physiologically-based Pharmacokinetic (PBPK) model of estradiol disposition in humans. Based on Sier et al_2017_estrogen PBPK_simple (MODEL1711210001), but with intrinsic (i.e. liver-mediated) clearance term replaced by a genome scale metabolic network. Extrahepatic clearance is still represented by as simple mass action Model was developed in the Multi-Formalism Interaction Network Simulator (MuFINS), as described in Wu et al 2017 (doi: 10.1038/npjsba.2016.32). relevant Software and tutorials can be found at http://sysbio3.fhms.surrey.ac.uk/mufins/

SUBMITTER: Nick Plant  

PROVIDER: MODEL1711210003 | BioModels | 2018-02-02

REPOSITORIES: BioModels

Dataset's files

Source:
altmetric image

Publications

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology.

Sier Joanna H JH   Thumser Alfred E AE   Plant Nick J NJ  

BMC systems biology 20171215 1


<h4>Background</h4>Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and proliferation during the menstrual cycle and pregnancy in women. The varied biological roles of estrogens in human health also make them a therapeutic target for contraception, mitigation of the adverse effects of the menopause, and treatment of estrogen-responsive tumours. In ad  ...[more]

Similar Datasets

2024-11-01 | GSE218438 | GEO
2021-09-09 | PXD021018 | Pride
2020-03-20 | MODEL2003190003 | BioModels
| PRJNA401422 | ENA
| 2123891 | ecrin-mdr-crc
2021-09-07 | PXD022995 | Pride
2024-09-02 | BIOMD0000000765 | BioModels
2021-02-26 | PXD024158 | Pride
2023-01-18 | MODEL2301090001 | BioModels
2005-01-01 | MODEL1006230040 | BioModels