Proteomics

Dataset Information

0

Quantitative LC-MS/MS Proteomics of human brain microvessels

ABSTRACT: We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases, nucleases and tight junction proteins in 22 human brain microvessel samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to predict drug disposition in the brain and permitting dose adjustment (precision dosing) in special populations of patients, such as those with dementia.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Zubida Al-Majdoub  

LAB HEAD: Jill Barber

PROVIDER: PXD021018 | Pride | 2021-09-09

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20170804_BarberJ_ZA_HB01.raw Raw
20170804_BarberJ_ZA_HB02.raw Raw
20170804_BarberJ_ZA_HB03.raw Raw
20170804_BarberJ_ZA_HB04.raw Raw
20170804_BarberJ_ZA_HB05.raw Raw
Items per page:
1 - 5 of 25
altmetric image

Publications

ABC transporters (ATP-binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantification of ABC transporters remains challenging because they are large and low-abundance transmembrane proteins. Here, we analysed 200 samples of crude and membrane-enriched fractions from human liver, kidney, intestine, brain microvessels and skin, by  ...[more]

Similar Datasets

Proteomics Quantitative LC-MS/MS Proteomics of human liver microsomes
2021-09-08 | PXD020910 | Pride
Proteomics Quantitative LC-MS/MS proteomics of human kidney microsomes
2021-08-30 | PXD020996 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human skin and LabSkin model
2021-09-08 | PXD020742 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of microsomal fractions from adult human livers
2021-09-09 | PXD021025 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of paediatric biliary atresia human liver microsomes
2021-09-09 | PXD020974 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human small intestine
2021-09-09 | PXD020987 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of paediatric human liver microsomes (set 2)
2021-09-09 | PXD020939 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of paediatric human liver microsomes
2021-09-09 | PXD020844 | Pride
Proteomics Quantitative LC-MS/MS Proteomics of human liver microsomes (healthy controls and normal-tumour from cancer patients)
2023-05-10 | PXD038776 | Pride
Transcriptomics Non-coding small RNA profiling by high throughput sequencing of bovine primary retinal microvascular endothelial cells
2012-02-13 | E-GEOD-31340 | biostudies-arrayexpress