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Terentyeva2015 - Mechanisms of XII activation

ABSTRACT: Mathematical model of the mechanism and kinetics of blood coagulation factor XII.

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1808160001 | BioModels | 2018-08-16

REPOSITORIES: BioModels

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Publications

Kinetics and mechanisms of surface-dependent coagulation factor XII activation.

Terentyeva Vladislava A VA Sveshnikova Anastasia N AN Panteleev Mikhail A MA

Journal of theoretical biology 20150714

Surface-induced activation of factor XII is critical part of the intrinsic pathway of blood coagulation. The mechanism of this process remains unclear: in particular, it is not known whether the initial amounts of factor XIIa, an active form of factor XII, are produced purely by factor XII contacting a surface or if traces of factor XIIa pre-exist. Furthermore, it is not known whether factor XII first has to bind to a surface before it can interact with the surface-bound factor XIIa in a two-dim ...[more]

PMID: 26187095

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