Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression analysis of TNF-alpha stimulated CaCo-2 cells


ABSTRACT: The series was designed to obtain gene expression patterns of TNF-alpha stimulated CaCo-2 cells. Keywords: TNF-alpha stimulation This series represents a group of 18 samples in 2 groups: 10 samples derived from not stimulated CaCo-2 cells, 8 samples from CaCo-2 cells stimulated with TNF-alpha in final concentration of 5 ng/ml for 60 min.

ORGANISM(S): Homo sapiens

SUBMITTER: Susanna Nikolaus 

PROVIDER: E-GEOD-10108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD.

Schulze H A HA   Häsler R R   Mah N N   Lu T T   Nikolaus S S   Costello C M CM   Schreiber S S  

Genes and immunity 20080313 3


Crohn's disease (CD) and ulcerative colitis (UC) are subforms of inflammatory bowel diseases (IBD). Genetic and environmental factors influencing the onset and course of the diseases have been recently identified. This study uses a two-step approach to detect genes involved in the pathogenesis of IBD by microarray analysis and real-time PCR (RT-PCR). In a first step, microarray expression screening was used to obtain tumour necrosis factor-alpha (TNF-alpha) induction profiles of two human cell l  ...[more]

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