Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anand Champak Patel
PROVIDER: E-GEOD-10211 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of immunology (Baltimore, Md. : 1950) 20080301 5
The epithelial surface is often proposed to actively participate in host defense, but evidence that this is the case remains circumstantial. Similarly, respiratory paramyxoviral infections are a leading cause of serious respiratory disease, but the basis for host defense against severe illness is uncertain. Here we use a common mouse paramyxovirus (Sendai virus) to show that a prominent early event in respiratory paramyxoviral infection is activation of the IFN-signaling protein Stat1 in airway ...[more]