Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells

ABSTRACT: The mechanism whereby IL-9 stimulated monocytes, promote proliferation of co-cultured ATL cells remains undefined. To obtain preliminary clues concerning this contribution, transcription profiles were obtained between monocytes derived from ATL patients and those derived from healthy donors as assessed by cDNA microarray. Keywords: disease state design The experiment included 3 biological replicate ATL samples and 3 biological replicate normal samples. The Stratagene Universal Human RNA Reference sample was used as a control.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Wadlmann

PROVIDER: E-GEOD-10789 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.

Chen Jing J Petrus Mike M Bryant Bonita R BR Phuc Nguyen Vinh V Stamer Mindy M Goldman Carolyn K CK Bamford Richard R Morris John C JC Janik John E JE Waldmann Thomas A TA

Blood 20080313 10

The etiologic agent of adult T-cell leukemia (ATL) is human T cell lymphotropic virus type I (HTLV-I). The HTLV-I protein Tax alters gene expression, including those of cytokines and their receptors, which plays an important role in early stages of ATL. Here we demonstrate that expression of interleukin-9 (IL-9) is activated by Tax via an NF-kappaB motif in its proximal promoter, whereas IL-9 receptor-alpha (IL-9Ralpha) expression is not induced by Tax. However, supporting a role for IL-9/IL-9Ra ...[more]

PMID: 18339896

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Dataset Information

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells

Publications

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.

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