Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human HeLa cells by hsa-mir-98 overexpression


ABSTRACT: Total RNA samples from three biological replicates in which the hsa-mir-98 was overexpressed in HeLa cells were profiled by gene expression. As negative control, we used total RNA samples from HeLa cells transfected with cel-mir-67 Experiment Overall Design: hsa-miR-98 transfection

ORGANISM(S): Homo sapiens

SUBMITTER: Vincenzo Alessandro Gennarino 

PROVIDER: E-GEOD-12092 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression by inducing RNA cleavage or translational inhibition. Most human miRNAs are intragenic and are transcribed as part of their hosting transcription units. We hypothesized that the expression profiles of miRNA host genes and of their targets are inversely correlated and devised a novel procedure, HOCTAR (host gene oppositely correlated targets), which ranks predicted miRNA target genes based on their anti-correlated expression  ...[more]

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