Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human pancreatic tumours in xenografts to investigate the antitumor activity and molecular effects of the novel Hsp 90 Inhibitor, IPI-504, in pancreatic cancer

ABSTRACT: Tumors from pancreatic cancer specimens obtained at surgery were used for efficacy testing and biologic analysis. These tumors were s.c. explanted in xenograft models for subsequent treatment experiments. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent. Experiment Overall Design: Five tumor samples were profiled in treated and untreated with IPI504. Untreated samples were profiled in duplicate. The overall design is to identify differentially expressed genes in IPI504 treated versus untreated.

ORGANISM(S): Homo sapiens

SUBMITTER: Aik Choon Tan 

PROVIDER: E-GEOD-12113 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cancer has not been studied. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent. In vitro, we show that pharmacologic inhibition of Hsp90 by IPI-504  ...[more]

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