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Murine spleen B cells miR181b vs control (G4122A)

ABSTRACT: Transcriptional profile of mouse primary spleen B cells overexpresing miR181b-GFP vectors compared to B cells overexpressing control-GFP vectors Keywords: Genetic modification Two-condition experiment: B-miR181b vs. B-control. Biological replicates: 1 control, 1 miR181b.

ORGANISM(S): Mus musculus

SUBMITTER: Almudena Ramiro

PROVIDER: E-GEOD-12156 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-181b negatively regulates activation-induced cytidine deaminase in B cells.

de Yébenes Virginia G VG Belver Laura L Pisano David G DG González Susana S Villasante Aranzazu A Croce Carlo C He Lin L Ramiro Almudena R AR

The Journal of experimental medicine 20080901 10

Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of chromosome ...[more]

PMID: 18762567

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microRNA expression profile of activated primary B cells and miR181b overexpressing primary B cells

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Project description:Transcriptional response by macrophages stimulated with selected cytokines or innate immune stimuli

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