Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Analyses of cyclin D1 function using a "genetic-proteomic" approach


ABSTRACT: We examined the transcriptional function of cyclin D1 in mouse development using two approaches. First, we queried association of cyclin D1 with the genome of E14.5 mouse embryos using ChIP-on-chip approach. We observed binding of cyclin D1 to several promoter regions. Second, we compared gene expression profiles between wild-type and cyclin D1-null retinas. We observed several transcripts with altered levels in cyclin D1-null organs. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Frederic Bienvenu 

PROVIDER: E-GEOD-13636 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. The full repertoire of cyclin D1 functions in normal development and oncogenesis is unclear at present. Here we developed Flag- and haemagglutinin-tagged cyclin D1 knock-in mouse strains that allowed a high-throughput mass spectrometry approach to search for cyclin D1-binding proteins in different mouse organs. In addition to cell cycle partners, we observed several proteins involved in trans  ...[more]

Similar Datasets

2010-05-15 | E-GEOD-13632 | biostudies-arrayexpress
2013-11-03 | E-GEOD-37094 | biostudies-arrayexpress
2010-05-04 | E-GEOD-18126 | biostudies-arrayexpress
2010-05-05 | E-GEOD-18178 | biostudies-arrayexpress
2010-05-04 | E-GEOD-21662 | biostudies-arrayexpress
2012-01-01 | E-GEOD-33829 | biostudies-arrayexpress
2010-06-24 | E-GEOD-22476 | biostudies-arrayexpress
2010-05-25 | E-GEOD-10883 | biostudies-arrayexpress
2011-06-06 | E-GEOD-28284 | biostudies-arrayexpress
2011-11-06 | E-GEOD-30736 | biostudies-arrayexpress