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A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18126: Methylation status in AG- and PG-derived cells and sperm GSE18178: Methylation status in human sperm Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Hitoshi Hiura 

PROVIDER: E-GEOD-21662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.

Hiura Hitoshi H   Sugawara Atsushi A   Ogawa Hidehiko H   John Rosalind M RM   Miyauchi Naoko N   Miyanari Yusuke Y   Horiike Tokumasa T   Li Yufeng Y   Yaegashi Nobuo N   Sasaki Hiroyuki H   Kono Tomohiro T   Arima Takahiro T  

Nucleic acids research 20100412 15


The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. To date, four paternally methylated DMRs have been identified in screens based on conventional approaches. These DMRs are linked to the imprinted genes H19, Gtl2 (IG-DMR), Rasgrf1 and, most recently, Zdbf2 which encodes zinc finger, DBF-type containing 2. In this study, we applied a novel methylated-DNA immunoprecipitation-on  ...[more]

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