Ontology highlight
ABSTRACT:
ORGANISM(S): Streptococcus pyogenes
SUBMITTER: Andrew Hollands
PROVIDER: E-GEOD-13656 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20081231 12
Epidemiological studies of group A streptococcus (GAS) have noted an inverse relationship between SpeB expression and invasive disease. However, the role of SpeB in the course of infection is still unclear. In this study we utilize a SpeB-negative M1T1 clinical isolate, 5628, with a naturally occurring mutation in the gene encoding the regulator RopB, to elucidate the role of RopB and SpeB in systemic virulence. Allelic exchange mutagenesis was used to replace the mutated ropB allele in 5628 wit ...[more]