Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Drosophila cells to FHV RNA1 replicon expression (replicon experiment)

ABSTRACT: Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to Flock House virus (FHV) replicon induction. Experiment Overall Design: Cultured S2 cells stably transfected with either a control replicon (pS2F1fs) or an FHV RNA1 replicon (pS2F1) were induced with 1 mM copper and we measured global transcript levels at 18 h after induction using Affymetrix Drosophila Genome 2.0 microarray chips.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: David Miller 

PROVIDER: E-GEOD-15467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication.

Castorena Kathryn M KM   Stapleford Kenneth A KA   Miller David J DJ  

BMC genomics 20100317

<h4>Background</h4>Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the assembly and function of positive-strand RNA virus replication complexes. However, the impact of specific lipid metabolism pathways in this process have not been well defined, nor have potential changes in lipid expression associated wit  ...[more]

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