Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Drosophila cells response to FHV RNA replication

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE15466: Transcriptional response of Drosophila cells to FHV infection (infection experiment); GSE15467: Transcriptional response of Drosophila cells to FHV RNA1 replicon expression (replicon experiment) Experiment Overall Design: Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: David Miller 

PROVIDER: E-GEOD-15469 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication.

Castorena Kathryn M KM   Stapleford Kenneth A KA   Miller David J DJ  

BMC genomics 20100317

<h4>Background</h4>Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the assembly and function of positive-strand RNA virus replication complexes. However, the impact of specific lipid metabolism pathways in this process have not been well defined, nor have potential changes in lipid expression associated wit  ...[more]

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