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Gene Expression Profiling of Malignant Peritoneal Mesothelioma Patient Tumor Samples

ABSTRACT: Gene expression profiles were generated from 41 consecutive surgically resected fresh frozen malignant peritoneal mesothelioma patient tumor samples to identify molecular prognostic factors. Patient tumor samples hybridized against the common reference (complementary DNA generated from human universal RNA), 41 tumor samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Sheelu Varghese

PROVIDER: E-GEOD-15627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma.

Varghese Sheelu S Chen Zhaorong Z Bartlett David L DL Pingpank James F JF Libutti Steven K SK Steinberg Seth M SM Wunderlich John J Alexander H Richard HR

Cancer 20100913 2

<h4>Background</h4>Malignant peritoneal mesothelioma (MPM) is a rare malignancy of the serosal membranes of the abdominal cavity. This cancer is ultimately fatal in almost all afflicted individuals; however, there is marked variability in its clinical behavior: Some patients die rapidly, and others survive for many years. In the current study, the authors investigated the molecular nature of MPM to obtain insights into the heterogeneity of its clinical behavior and to identify new therapeutic ta ...[more]

PMID: 20839315

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