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Methylation profile in breast cancer

ABSTRACT: Agilent CpG microarray in combination with enriched methylated DNA by a MBD protein were carried out in each pool of genomic DNA from primary breast tumor and matched adjacent normal tissues. 1.Common reference vs enriched methylated DNA in tumor 2. Common reference vs enriched methylated DNA in adjacent normal 3. Then compare two data indirectly

ORGANISM(S): Homo sapiens

SUBMITTER: Myung Soon Kim

PROVIDER: E-GEOD-27374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide identification of OTP gene as a novel methylation marker of breast cancer.

Kim Myung Soon MS Lee Jinsun J Oh Taejeong T Moon Youngho Y Chang Eilsung E Seo Kwang Sun KS Hoehn Benjamin Douglas BD An Sungwhan S Lee Jeung-Hoon JH

Oncology reports 20120217 5

Aberrant DNA methylation occurs early and frequently in tumorigenesis. Identification of DNA methylation biomarkers is a field that provides potential for improving the clinical process of breast cancer diagnosis. We utilized a genome-wide technique, methylated DNA isolation assay (MeDIA), in combination with high-resolution CpG microarray analysis to identify hypermethylated genes in breast cancer. Among differentially methylated genes ...[more]

PMID: 22366991

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