Transcription profiling of livers from 74-day old male rats fed vitamin A sufficient or vitamin A deficient diet for 53 days
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Howard Edenberg
PROVIDER: E-GEOD-1600 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.
McClintick Jeanette N JN Crabb David W DW Tian Huijun H Pinaire Jane J Smith Jennifer R JR Jerome Ronald E RE Edenberg Howard J HJ
The Journal of nutritional biochemistry 20050919 5
Vitamin A (retinol) metabolites are ligands for transcription factors that regulate many genes. The liver is the main storage depot for retinol and plays a role in vitamin A homeostasis. To better understand the effects of vitamin A deficiency on liver gene expression, we produced retinol deficiency in male rats by feeding a diet low in retinol for 53 days after weaning and examined the effects on gene expression in liver using Affymetrix oligonucleotide microarrays. We detected expression of 41 ...[more]
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