Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse deficient for Fibrillin-1


ABSTRACT: Different fibrillin-1 mutant mice

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Judge 

PROVIDER: E-GEOD-1852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.

Ng Connie M CM   Cheng Alan A   Myers Loretha A LA   Martinez-Murillo Francisco F   Jie Chunfa C   Bedja Djahida D   Gabrielson Kathleen L KL   Hausladen Jennifer M W JM   Mecham Robert P RP   Judge Daniel P DP   Dietz Harry C HC  

The Journal of clinical investigation 20041201 11


Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including Marfan syndrome (MFS), an autosomal-dominant connective tissue disorder caused by mutations in fibrillin-1. Fibrillin-1 contributes to the regulated activation of the cytokine TGF-beta, and enhanced signaling is a consequence of fibrillin-1 deficiency. We thus hypothesized that increased TGF-beta signaling may contribu  ...[more]

Similar Datasets

2004-10-20 | GSE1852 | GEO
2013-05-31 | E-GEOD-36778 | biostudies-arrayexpress
2023-05-31 | PXD029834 | Pride
2007-11-06 | E-GEOD-479 | biostudies-arrayexpress
| PRJNA90469 | ENA
| EGAS00001000729 | EGA
2009-01-14 | E-GEOD-8454 | biostudies-arrayexpress
2010-03-09 | GSE15293 | GEO
| S-EPMC3163732 | biostudies-literature
2022-05-20 | PXD027096 | Pride