Unknown,Transcriptomics,Genomics,Proteomics

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INO80-regulated genes in S-phase after MMS treatment


ABSTRACT: This is transcription analysis of genes regulated by the INO80 chromatin remodeling complex in S-phase of the cell cycle after MMS treatment. Wildtype and ino80 mutant cells were first synchronized at G1 using alpha-factor, the cells were released in to S-phase in the presence of 0.02% MMS. After 45 minutes, total RNA was isolated and analyzed to identify genes that are regulated by INO80 under such conditions.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: X Shen 

PROVIDER: E-GEOD-18555 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Involvement of a chromatin remodeling complex in damage tolerance during DNA replication.

Falbo Karina B KB   Alabert Constance C   Katou Yuki Y   Wu Su S   Han Junhong J   Wehr Tammy T   Xiao Jing J   He Xiangwei X   Zhang Zhiguo Z   Shi Yang Y   Shirahige Katsu K   Pasero Philippe P   Shen Xuetong X  

Nature structural & molecular biology 20091025 11


ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling complex in the DNA damage tolerance pathways. Whereas INO80 is necessary for the resumption of replication at forks stalled by methyl methane sulfonate (MMS), it is not required for replication fork colla  ...[more]

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