Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: F Uckun
PROVIDER: E-GEOD-18798 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Uckun Fatih M FM Qazi Sanjive S Ma Hong H Tuel-Ahlgren Lisa L Ozer Zahide Z
Proceedings of the National Academy of Sciences of the United States of America 20100129 7
We provide unprecedented genetic and biochemical evidence that the antiapoptotic transcription factor STAT3 serves as a substrate for SYK tyrosine kinase both in vitro and in vivo. Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes. STAT3 activation after oxidative stress (OS) is strongly diminished in DT40 chi ...[more]