Proteomics

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Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.


ABSTRACT: Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Jeroen Demmers  

LAB HEAD: Jeroen AA Demmers

PROVIDER: PXD001455 | Pride | 2015-01-23

REPOSITORIES: Pride

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Publications

Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster.

Sap Karen A KA   Bezstarosti Karel K   Dekkers Dick H W DH   van den Hout Mirjam M   van Ijcken Wilfred W   Rijkers Erikjan E   Demmers Jeroen A A JA  

Proteomics 20150114 4


The ecdysone signaling pathway plays a major role in various developmental transitions in insects. Recent advances in the understanding of ecdysone action have relied to a large extent on the application of molecular genetic tools in Drosophila. Here, we used a comprehensive quantitative SILAC MS-based approach to study the global, dynamic proteome of a Drosophila cell line to investigate how hormonal signals are transduced into specific cellular responses. Global proteome data after ecdysone tr  ...[more]

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