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Genome-wide mapping of Fos binding site (K562)

ABSTRACT: Proto-oncogene c-Fos is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Fos dimerizes with another transcription factor Jun to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Map binding sites of transcription factor Fos in the genome of K562 cells. The K562 input data has been deposited in GEO as GSM325934.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Wilson

PROVIDER: E-GEOD-19546 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Close association of RNA polymerase II and many transcription factors with Pol III genes.

Raha Debasish D Wang Zhong Z Moqtaderi Zarmik Z Wu Linfeng L Zhong Guoneng G Gerstein Mark M Struhl Kevin K Snyder Michael M

Proceedings of the National Academy of Sciences of the United States of America 20100205 8

Transcription of the eukaryotic genomes is carried out by three distinct RNA polymerases I, II, and III, whereby each polymerase is thought to independently transcribe a distinct set of genes. To investigate a possible relationship of RNA polymerases II and III, we mapped their in vivo binding sites throughout the human genome by using ChIP-Seq in two different cell lines, GM12878 and K562 cells. Pol III was found to bind near many known genes as well as several previously unidentified target ge ...[more]

PMID: 20139302

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Genome-wide mapping of Jun binding site (K562)

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2009-12-31 | E-GEOD-19545 | biostudies-arrayexpress

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2009-12-31 | E-GEOD-19547 | biostudies-arrayexpress

Genome-wide mapping of RNA Polymerase II binding sites

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2009-12-31 | E-GEOD-19548 | biostudies-arrayexpress

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Genome-wide mapping of RNA Pol II binding site (GM12878)

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2009-12-31 | E-GEOD-19550 | biostudies-arrayexpress

Genome-wide mapping of RNA Pol III binding site (GM12878)

Project description:We report the results of chromatin immunoprecipitation following by high-thoughput sequencing (ChIP-Seq) using the GA II platform from Illumina for the human RNA Polymerase III in GM12878 cells. We have also generated a sequenced input DNA datasets for GM12878 cells. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Map binding sites of RNA Polymerase III in the genome of GM12878 cells.

2009-12-31 | E-GEOD-19549 | biostudies-arrayexpress

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