Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Philippe Collas
PROVIDER: E-GEOD-19795 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sørensen Anita L AL Jacobsen Bente Marie BM Reiner Andrew H AH Andersen Ingrid S IS Collas Philippe P
Molecular biology of the cell 20100421 12
Mesenchymal stem cells (MSCs) isolated from various tissues share common phenotypic and functional properties. However, intrinsic molecular evidence supporting these observations has been lacking. Here, we unravel overlapping genome-wide promoter DNA methylation patterns between MSCs from adipose tissue, bone marrow, and skeletal muscle, whereas hematopoietic progenitors are more epigenetically distant from MSCs as a whole. Commonly hypermethylated genes are enriched in signaling, metabolic, and ...[more]