Differential methylation profiling of colon tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Eddy van Roon
PROVIDER: E-GEOD-21181 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
van Roon Eddy H J EH de Miranda Noël F C C NF van Nieuwenhuizen Merlijn P MP de Meijer Emile J EJ van Puijenbroek Marjo M Yan Pearlly S PS Huang Tim H-M TH van Wezel Tom T Morreau Hans H Boer Judith M JM
European journal of human genetics : EJHG 20101208 3
DNA methylation is a hallmark in a subset of right-sided colorectal cancers. Methylation-based screening may improve prevention and survival rate for this type of cancer, which is often clinically asymptomatic in the early stages. We aimed to discover prognostic or diagnostic biomarkers for colon cancer by comparing DNA methylation profiles of right-sided colon tumours and paired normal colon mucosa using an 8.5 k CpG island microarray. We identified a diagnostic CpG-rich region, located in the ...[more]
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