GBM_SC_retinoic acid_gene_expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shuli Xia
PROVIDER: E-GEOD-21336 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition.
Ying M M Wang S S Sang Y Y Sun P P Lal B B Goodwin C R CR Guerrero-Cazares H H Quinones-Hinojosa A A Laterra J J Xia S S
Oncogene 20110307 31
It is necessary to understand mechanisms by which differentiating agents influence tumor-initiating cancer stem cells. Toward this end, we investigated the cellular and molecular responses of glioblastoma stem-like cells (GBM-SCs) to all-trans retinoic acid (RA). GBM-SCs were grown as non-adherent neurospheres in growth factor supplemented serum-free medium. RA treatment rapidly induced morphology changes, induced growth arrest at G1/G0 to S transition, decreased cyclin D1 expression and increas ...[more]
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