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Microarray analysis of developing mouse cortex reveals regulation of ribosomal protein mRNAs throughout development

ABSTRACT: Neocortical development is spatiotemporally regulated by exogenous factors, but the mechanism regulating timed specificity of neocortical mRNA translation is unknown. We find that active mRNA translation sites (polysomes) contain ribosomal protein subsets that undergo dynamic spatiotemporal rearrangements during mouse neocortical development. Two samples of cortext total RNA each from four embryonic time points were collected.

ORGANISM(S): Mus musculus

SUBMITTER: Ronald Hart

PROVIDER: E-GEOD-61751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Post-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.

DeBoer E M EM Kraushar M L ML Hart R P RP Rasin M-R MR

Neuroscience 20130530

The mature neocortex is a unique six-layered mammalian brain region. It is composed of morphologically and functionally distinct subpopulations of primary projection neurons that form complex circuits across the central nervous system. The precisely-timed generation of projection neurons from neural stem cells governs their differentiation, postmitotic specification, and signaling, and is critical for cognitive and sensorimotor ability. Developmental perturbations to the birthdate, location, and ...[more]

PMID: 23727006

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