Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: James Carrington
PROVIDER: E-GEOD-22252 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cuperus Josh T JT Carbonell Alberto A Fahlgren Noah N Garcia-Ruiz Hernan H Burke Russell T RT Takeda Atsushi A Sullivan Christopher M CM Gilbert Sunny D SD Montgomery Taiowa A TA Carrington James C JC
Nature structural & molecular biology 20100618 8
RNA interference pathways can involve amplification of secondary siRNAs by RNA-dependent RNA polymerases. In plants, RDR6-dependent secondary siRNAs arise from transcripts targeted by some microRNAs (miRNAs). Here, Arabidopsis thaliana secondary siRNAs from mRNA as well as trans-acting siRNAs are shown to be triggered through initial targeting by a 22-nucleotide (nt) miRNA that associates with AGO1. In contrast to canonical 21-nt miRNAs, 22-nt miRNAs primarily arise from foldback precursors cont ...[more]