Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

B-AP15, a novel proteasome inhibitor

ABSTRACT: Microarray based mRNA profiling was used to identify the mechanism of action for the small molecule b-AP15. MCF7 cells were treated with b-AP15 (1µM) or vehicle for 6 hours, followed by RNA isolation and gene expression analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Mårten Fryknäs

PROVIDER: E-GEOD-24150 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Natural compound screening

Project description:Transcriptional expression data for bioactive small molecules for mechanism identification. Keywords: Expression profiling by array MCF7 cells were treated with either NSC76022 (thaspine) or DMSO control for six hours, to identify compound specific gene regulation.

2009-10-04 | E-GEOD-13124 | biostudies-arrayexpress

PCPTC screening

Project description:Primary cultures of patient tumor cells (PCPTC) were used in a cell-based cytotoxicity screen. Microarray-based mRNA profiling was used to identify the mechanism-of-action for the small molecule VLX 50. MCF7 cells were treated with the PCPTC screening hit VLX 50 or DMSO control for 6h prior to RNA isolation. One sample per treatment. Data were analyzed using both MAS5.0 and RMA.

2011-09-08 | E-GEOD-24027 | biostudies-arrayexpress

Spheroid active compound

Project description:Transcriptional expression data for a bioactive small molecule for mechanism identification. MCF7 cells were treated with either the compound NSC620358 or DMSO (control) for 6h prior to RNA isolation, to identify drug specific gene expression changes.

2013-06-21 | E-GEOD-30141 | biostudies-arrayexpress

VLX60 characterization

Project description:Microarray based mRNA profiling was used to identify the mechanism of action for the small molecule VLX60. MCF7 cells were treated with the drug candidate VLX60 for 6h prior to RNA isolation

2015-05-28 | E-GEOD-58526 | biostudies-arrayexpress

Spheroid model system

Project description:Microarray based mRNA profiling was used to charactarize and compare the gene expression in cells grown as monolayer or spheroids. Microarray based mRNA profiling was used to charactarize and compare the gene expression in cells grown as monolayer or spheroids.

2012-08-31 | E-GEOD-36666 | biostudies-arrayexpress

Microarray analysis of MCF7 cells treated with NSC 59687 (Oxyphenisatin Acetate)

Project description:NSC 59687 (oxyphenisatin acetate) is a novel anti-cancer agent with selectivity for breast and ovarian cell lines To elucidate the transcripts differentially regulated following treatment with Oxyphenisatin acetate (NSC 59687) MCF7 cells were treated with 10 microM NSC 59687 for 24 hours followed by RNA extraction, cDNA synthesis and microarray analysis using Affymetrix huU133 plus 2.0 arrays

2013-03-13 | E-GEOD-45046 | biostudies-arrayexpress

Expression data in PBMCs from SLE patients and controls

Project description:Peripheral blood mononuclear cells were collected from SLE patients in an observational study performed at the University of Michigan Blood microarray expression data were used to confirm the presence of an Interferon signature and identify additional surrogate genes RNA from PBMCs of SLE patients and normal donor controls were obtained for one time point and were profiled on Affymetrix arrays

2015-03-31 | E-GEOD-50772 | biostudies-arrayexpress

Gene expression in canine uterine bacterial infection

Project description:The study was undertaken to analyze the effect of canine uterine bacterial infection (Pyometra) on local gene expression patterns in the uteri. The results show profound upregulation of various expected genes related to both the innate and innate immune system. In addition, there was a marked upregulation of many genes associated with proteolysis. Moreover, the bacterial disease resulted in downregulation of a large number of homeobox and zinc finger transcription factors. Keywords: Expression profiling by array Gene expression patterns in the uterus from dogs with pyometra disease compared to healthy dogs. 4 replicates each.

2010-08-20 | E-GEOD-17878 | biostudies-arrayexpress

Expression data from induced astrocytes , primary astrocyte and MEFs

Project description:MEFs treated by compounds for 25 days can be induced into astrocytes. In induced astrocytes, specific astrocytes-related sets of genes are up-regulated, but fibroblasts-related genes are down-regulated. The induced cells sorted for GFP-positive cells by flow cytometry and primary astrocytes and MEFs were parepared for RNA extraction and hybridization on Affymetrix microarrays. We sought to compare the induced astrocytes with primary astrocytes and MEFs.

2016-07-07 | E-GEOD-81927 | biostudies-arrayexpress

Expression changes in cultured endothelial cells upon infection with HHV-8

Project description:Tert-immortalized microvascular endothelial (TIME) cells are infected with human herpesvirus (HHV-8) or mocked infected to determine expression changes upon infection. Three samples to TIME cells are infected with HHV-8 and three samples are mock-infected.

2011-07-31 | E-GEOD-27136 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data