Dataset Information
Natural compound screening
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mårten Fryknäs
PROVIDER: E-GEOD-13124 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PloS one 20091002 10
<h4>Background</h4>Natural product structures have high chemical diversity and are attractive as lead structures for discovery of new drugs. One of the disease areas where natural products are most frequently used as therapeutics is oncology.<h4>Method and findings</h4>A library of natural products (NCI Natural Product set) was screened for compounds that induce apoptosis of HCT116 colon carcinoma cells using an assay that measures an endogenous caspase-cleavage product. One of the apoptosis-ind ...[more]
