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Transcription profiling of rat PPARgamma activation in pancreating islets treated with the thiazolidinedione GW-347845 or adenoviral PPARgamma1

ABSTRACT: Impact of PPAR gamma overexpression and activation on rat pancreatic islet gene expression profile analyzed with oligonucleotide microarrays.

Note that the data files GSM49668.txt and GSM49714.txt as downloaded from GEO are identical.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sujoy Ghosh

PROVIDER: E-GEOD-2582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Impact of PPARgamma overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays.

Parton Laura E LE Diraison Frédérique F Neill Suzanne E SE Ghosh Sujoy K SK Rubino Mark A MA Bisi John E JE Briscoe Celia P CP Rutter Guy A GA

American journal of physiology. Endocrinology and metabolism 20040504 3

Peroxisome proliferator-activated receptor-gamma (PPARgamma) serves as a target for the thiazolidinedione class of antidiabetic drugs and is an important regulator of adipose tissue differentiation. By contrast, the principal target genes for PPARgamma in the pancreatic islet and the impact of their induction on insulin secretion are largely undefined. Here, we show that mRNAs encoding both isoforms of rodent PPARgamma, gamma1 and gamma2, are expressed in primary rat islets and are upregulated b ...[more]

PMID: 15126236

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