Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): vitamin B12 deficiency
SUBMITTER: Alexander Sternberg
PROVIDER: E-GEOD-2779 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sternberg Alexander A Killick Sally S Littlewood Tim T Hatton Chris C Peniket Andy A Seidl Thomas T Soneji Shamit S Leach Joanne J Bowen David D Chapman Claire C Standen Graham G Massey Edwin E Robinson Lisa L Vadher Bipin B Kaczmarski Richard R Janmohammed Riaz R Clipsham Kim K Carr Andrew A Vyas Paresh P
Blood 20050802 9
Early, low-risk International Prognostic Scoring System (IPSS) myelodysplastic syndrome (MDS) is a heterogeneous disorder where the molecular and cellular hematopoietic defects are poorly understood. To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells from normal-karyotype, low-blast-count MDS patients, age-matched controls, and patients with non-MDS anemia. Given the heterogeneity of early MDS, a surprisingly consistent finding was decrease ...[more]