Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jacob Biesinger
PROVIDER: E-GEOD-28084 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Seo Young-Kyo YK Jeon Tae-Il TI Chong Hansook Kim HK Biesinger Jacob J Xie Xiaohui X Osborne Timothy F TF
Cell metabolism 20110401 4
Sterol regulatory element-binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we used genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs. A Gene Ontology (GO) analysis suggests SREBP-2 target ...[more]