Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: naimei tang
PROVIDER: E-GEOD-28616 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20111005 10
<h4>Background</h4>Bisbenzimides, or Hoechst 33258 (H258), and its derivative Hoechst 33342 (H342) are archetypal molecules for designing minor groove binders, and widely used as tools for staining DNA and analyzing side population cells. They are supravital DNA minor groove binders with AT selectivity. H342 and H258 share similar biological effects based on the similarity of their chemical structures, but also have their unique biological effects. For example, H342, but not H258, is a potent ap ...[more]